> If you have been given opioids for pain, did they work?
They make a huge difference to my current near-constant headaches (cause unknown). Non-opioids (high dose ibuprofen, naproxen, amitriptyline etc.) make little to no difference, but fairly weak opioids (codeine, tramadol) make a noticeable difference. I generally react well to them - low doses have a pronounced analgesic effect without side-effects (euphoria [obviously it is noticed at higher doses, but I don't need that for adequate pain relief] etc.), and they don't cause dependence (stopped the tramadol cold turkey after ~1 years use, and was completely fine other than the headaches returning).
As with pretty much any drug, the individual effects are fairly variable. I tried zopiclone for insomnia, and it produced unpleasant side-effects (rooms looked to be filled with yellow light, even during the night, and memory issues - being in one room then suddenly finding yourself in another with no memory of the intervening minutes is extremely unnerving).