EC2 is significantly more expensive (expressed as percent change) than VPS when you total up bandwidth etc.
the problem with the basic 'small' instances is that if there are system problems, you lose your storage. Sure, you can get around this by paying extra for EBS, but it's another problem you need to deal with (and pay for) that is largely taken care of on most VPSs. (which isn't to say you will never have data loss on a VPS, but all the major providers mirror disk, so it should be fairly rare.)