We've been using NSIS 2.x on and deploying for Windows 10 for a long time now, without any problems. Is there something in particular with regards to Windows 10 compatibility that this release brings to the table?
https://github.com/geary/jklmouse/blob/master/AutoHotkey/Sou...
Or were you saying that your installer runs elevated and installs to Program Files, and also wants to write some files to the user profile? I would think that should just work?
Shameless plug: JKLmouse gives you home row mouse control in nearly every Windows app. It's like MouseKeys but doesn't require a numeric keypad, so it works on laptop keyboards. Not too many people know about it; I wrote it for my own use years ago (first in C, then later in AutoHotkey). It is so nice to be able to move the mouse pointer pixel by pixel.