I've tried on a few occasions to really like Lisp. I love it's simplicity and recursiveness. The "code as data, data as code" thing is really cool.
But I love static typing. Not only for "safety-net" reasons, where the compiler lets you know that you've broken stuff, but also for documentation reasons (I don't have to guess at the shape of each "c" in "cs" in "(mapcar some-fun cs)", I can just look at its type and know its shape), and I really like it when that type system lets me be more expressive, like in MLs (where I can pattern-match by the various members of an ADT and destructure them as I go).
I also find that idiomatic Lisp likes to nest things too much to be really readable for me. If I don't have types to tell me how the data's being transformed, at least give me named functions and well-named variables instead of very-deeply-nested anonymous functions everywhere.
And finally, I've never been completely convinced that macros are a great idea. They're far too easily abused to create "the Scala problem" of having code in language X that is still unrecognizable to someone else who also writes in language X.