Accord to the movie Sugar Coated (on Netflix here in Canada) and Dr. Lustig there is no meaningful difference between HFCS and normal sugar -- they are equally quite bad for you. Switching from HFCS to cane sugar will achieve nothing I believe if you keep the sugar intake the same.
What I believe happened is that at the same time HFCS came on the market there was also a larger push to put sugar into a lot of things in place of fat.
Thus the introduction of HFCS seems to correlate with the North America weight problem but the North American weight problem also correlates with the increase in sugar in our diet -- and I understand from Sugar Coated and Dr. Lustig that is the causitive correlation.