I think abandonment of the Von Neumann paradigm will be crucial for AI. For decades we have labored under the misguided assumption that the brain is isomorphic to the Von Neumann architecture, with "memory banks" and "processing units." This approach has failed.
Admittedly, Lisp was once the first choice for AI research, and it did not readily lead us into the promised land either. Perhaps a functional approach is not radical enough :)