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So get there a little early, and ask to use the restroom. Or ask to use it on your way out.

Usually you're there for a couple hours, it's easy to sneak out in between 2 interviews for 2 minutes.

Before, after, or during multiple interviews. That being said, if you have an individual interview that lasts more than 90 minutes you could also excuse yourself briefly if you need to use the bathroom.

What's the big deal?