Maybe AI, space stuff or immortality - essentially the same thing. First of all I think these are overrated. The fun thing about these is the thought that "holy fuck we will actually do it!!". When it is there it will be like commercial aviation.
And even if you truly want to accomplish them by all means, the best strategy I can come up with is a) get the best of the best and b) throw all your money at them. If you perform a Gleichschaltung it will definitely harm your ability to throw money. So my dictatorship would consist mostly of cost cutting, economic incentives, educational reforms, reducing administration costs - essentially what every government claims to try anyway.