I still rely heavily on Mathematica, since the notebook interface won me over years and years ago. I think the next Mathematica paradigm to be redone in JupyterLab is easy connections to data without all the connection string fuss. You can just put in some basic phrases in Mathematica, and you are connected to the data, albeit curated by Wolfram, but still simple and immediate.

I can link to Mathematica from NetLogo and other programs I use too.