I'm aware there is a setting which has to do with subpixel rendering or whatever this is called, I tried switching it on and off for no perceivable visual change. So I gave up on Chrome.
IE also has had broken font rendering since they moved to subpixel rendering several years ago, but at least it draws fonts in a strong and dark fashion making them more readable than in Chrome.
Personally, I design for Firefox which I consider the gold standard of web development. Then, at some intervals I check if things are okay in IE and Chrome and usually they are fine. Chrome was useful once in helping me spot some sort of a race condition, its developer tools also conveniently allow you to quickly bypass caching for testing purposes, but other than that I found it useless and unusable.