Virtually no one calibrates their monitor so your carefully defined 24bit colours are going to hit eyeballs in all sorts of different forms.
Due to poor LCD quality, aging backlights and operating system configuration differences, all the parameters that affect color can vary wildly: gamma, color primaries... There's no guarantee of what #0044cc will look like, nor is there any guarantee that it would be perceptually about twice as bright as #002266.
At least Mac OS X 10.6 has finally switched to "PC gamma" (2.2) by default, so that eliminates one source of endless confusion about digital color.
Even in real life, our eyes are not calibrated the same. It is the contrast and relativity that makes things stand out and fade away.