Since most of Brotli's improvements over its ancestor LZ77 are due to its large, hardcoded, text-corpus dictionary [1], most of the algorithm's strengths would be wasted on binary data like images.

Zopfli, from the same people, is a DEFLATE encoder, so it can be used in PNG [2] and this has already been added to some optimizers, e.g. AdvanceCOMP [3]

[1] https://gist.github.com/klauspost/2900d5ba6f9b65d69c8e [2] https://github.com/google/zopfli/commit/337d27f25ef15a6cf34f... [3] http://www.advancemame.it/doc-advpng.html