+ interestingly the EU referendum was technically only advisory - but parliament would be mad to ignore it.
For a very small value of "meaningful", I signed a petition when the government made suggestions they would be moving businesses to submitting tax returns four times a year. The response was not actually a change in policy but a pretty good explanation of the miscommunication over what they were actually planning to do and why it wasn't worth getting worried about. So at least as a way to get the government to explain their intentions more clearly, it worked.
https://www.theguardian.com/world/2009/sep/11/pm-apology-to-...
A complete list that were debated is at https://petition.parliament.uk/petitions?state=debated