I think the next Scottish referendum will be a much harder decision for each voter personally. The previous one obvious wasn't a throw-away decision either but Scotland and England being separate EU member states would have meant little difference in daily live for most people.

Now the next referendum will be a lot more significant since it'll effectively be a UK vs EU decision. Either you follow the English into isolation or you suddenly have a very real border between England and Scotland with customs&immigrations checkpoints and similar things.