(Note that "assignment" to a variable is "meta" in a functional language (and you might want to use a "roll back 'worlds' mechanism" (like transactions) for safety when this is needed.)
This is a parallel to various kinds of optimization (many of which violate module boundaries in some way) -- there are ways to make this a lot safer (most languages don't help much)
A lot of interesting things tend to happen when you introduce invariants, including "everything-is-a" invariants. Everything is a file, everything is an object, everything is a function, everything is a relation, etc.
For example in Lisp, code is data and data is code (aka homoiconicity). This makes it very convenient to write macros (i.e. functions that accept and return executable code).
Unsafe meta-programming would be like the C pre-processor whose aptness for abuse make it a leading feature of IOCCC entries.