Why is that relevant? That's orthogonal to whether it is healthy or unhealthy. There's no reason, based on that information, that I should expect it to be any more or less toxic than Splenda. I mean, the wrong 100% natural mushroom will kill you pretty dead.
[1] http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrs...
Honestly, other than fear of 'teh chemicals,' I can't think of a reason.
You are making the false assumption "natural" foods are a correlated group as far as health goes. This is empirically false (ignoring the fact that natural has no scientific definition to begin with). Studying sucrose won't inform you of the dangers of cyanide though both are "natural".
The exception is if we can prove the two operate under the same fundamental mechanisms within the body. But there's nothing different about natural growing plants and man made substances under this sort of research. A molecule is a molecule.
(Not trolling, seeking honest clarification)
But, looking at what generations of long-lived people tend to eat[1] is probably a reasonable guide to nutrition and health. Manufactured/artificial stuff simply isn't on that list since that stuff hasn't been around long enough to be part of a multi-generational study.
[1] https://www.ted.com/talks/dan_buettner_how_to_live_to_be_100...
The post you replied to has already refuted your argument. We evolved with poisonous mushrooms in our environment and our body's "means of dealing with it" are to die. That's hardly the gold standard for biological responses, don't you think?
The fact that it's present in large quantities in at least one living organism shows that it's not fundamentally incompatible with life. And that's especially true in this case, where (according to Wikipedia) there is a 1,500 year history of human use. So all else being equal, I would expect it to be more likely to be safe than some random chemical with no basis in nature.
Out of the 2,000 species of mushrooms in North America, there are maybe 10 that are deadly poisonous. You think your chances of dying after randomly mixing up some unknown chemicals in a lab are really less than 1 in 200?