Do you have extensions installed? Nightly has E10s default-enabled, and there's currently still pretty bad performance problems when using certain extensions with E10s.
Basically, extension developers can "shim" their add-ons, which, as far as I understand it, tells Firefox that it has to handle things which are affected by the extension in a single-threaded way, again.
And because the world is a grim place, this doesn't just get you back to non-E10s performance, but is actually worse.
Eventually, add-on developers should properly port their extensions to E10s and then those performance problems will disappear, but at the moment they are still very frequent and when Mozilla rolls out E10s, they will also only default-enable it for users without extensions for this exact reason.
If you want to troubleshoot this, I would recommend looking at about:performance and www.arewee10syet.com.
You should probably check how performance is in a new profile[0] first, though, just to make sure that you're not trying to replace extensions when it might be caused by something else.
[0]: https://support.mozilla.org/en-US/kb/profile-manager-create-...