- Maine jobs are low-paying and few-and-far-between. Not an issue if you're positive you can line-up recurring remote jobs, but be honest with yourself.
- Income taxes are pretty high.
- You'll want to live in Portland.
- Portland is "expensive" for rent (you're very lucky to get a nice 1br for 1400/mo, with rents on the rise due to out-of-state purchasing of condos for rental-income or airBNB/subsidizing owner-seasonal housing)
- Portland is a driving city. You _do_ have a car, right?
- Food/drink/going-out is a little below NYC prices (they can get away with it due to out-of-state travelers). There are great restaurants, but most are mediocre to bad. The beer's great though. Enjoy your beer per hour, as you'll be driving home.
- Everything is closed by 11 on weekends.
- Housing costs are steeply on the rise and the local culture is on the decline -- it's not a secret Maine is beautiful, and most of the population is retirement age (oldest in the nation!), so the culture is whatever sells to out-of-state money. Hope you're cool with those taxes going up to support the baby boomers leaving the workforce.