I tried Nix on OS X after a recent HN topic suggested it. I hate Homebrew with a passion (it's fine initially but, over time, it's always created a hard-to-clean-up mess for me), so I was looking for something that could replace it for most unixy things I need to install.
I immediately ran into a showstopper bug that they've had for some time now. Apparently, they've focused on NixOS and the CA certificate configuration is borked on other platforms. This means Git, Curl and anything else that tries to use the standard OS certificate store will fail certificate validation. I know it's only one issue, but it was pernicious enough for me to nuke my Nix install and move onto something else.
At the moment, the best I can find for OS X is Rudix. The selection of available software is pathetic compared to Homebrew and Nix, but a lot of the core stuff is there and it's all packaged as a .pkg, which makes it really easy to cleanly erase installed software.