I've recently written a Blender addon using Python that came to just over 1000 LOC. Not big at all and yet already I was running into problems that are just non existent in static languages. I couldn't refactor variable names and had to manually replace the text which was very error prone, I had no help from the language about whether I had referenced a variable by the right name as it would just create a new one, no 'goto defintion' and instead I was reduced to scrolling or ctrl+F, no braces to tell me where scope starts and ends (which you wouldn't think mattered, but only relying on indentation actually gets quite messy), and no contextual knowledge of the blender APIs unless I knew what to Google and it often came down to someone asking the same question on stackexchange.

The only way I could manage it was to write tiny functions, so I could literally eyeball the scope and keep all the details in my short term memory. I would not recommend using this language for larger projects.