I must admit finding it hard to make the distinction you suggest.
Would the American Civil War be a big guy beating up on a little guy? After all, the North was ten times as populous, and many, many times as rich. Nobody on either side thought the war would last very long.
How about the Romans and the Germanic tribes? Nobody in their right mind thought those Barbarians could stand up against the full might of the Roman Empire very long.
Wars are fought until one side decides to stop fighting. This means that "big guy/little guy" wars and "outcome is uncertain" wars don't seem to be that different. In fact the determining factor would seem to be how easy it is for one side to quit. But how would you know how much it would take to make the other side stop fighting until it actually happens? From the history I've seen, when both sides are very intimate with each other's language and culture -- that's when some of the deadliest, nastiest conflicts take place.