If you've worked remotely for a big company, what did you think of it?
You might want to look for companies that believe in a ROWE: results-only work environment. These are the ones with unlimited PTO. Best Buy corporate was the first to popularize it.
I'm doing some recruiting for a startup that will consider remote if you've got very relevant experience (in this case, are a Spark committer). It can also be that way on the domain side of things.
For instance, I just told a friend who needs to find work fast to contact his company's competitors. In this case, there is no danger of IP theft (and I'd never recommend doing anything unethical) since they are botching up the tech pretty badly, hence the desire to leave. Would be worth it to snag a top technologist at your competitor, even if s/he's remote.