Entrepreneurism: The Age Gap
entrepreneur.venturebeat.com
entrepreneur.venturebeat.com
A tolerant spouse makes all the difference.
You also need separate finances to impose a loss limit. The spouse's income, except for a pre-agreed amount, is not to be used for a startup. That's for paying the mortgage and the kids' expenses.
To answer your question: I think so. Overnight success at 28 is the exception, not the rule, because the experiences and contacts one gains as one gets older are valuable. There's a tendency to focus on these outliers, but most successes happen in the 40s. The same is true in research: a few mathematicians are known for peaking (or dying, like Galois) in their 20s, but most will do their best work in middle age. That is less true in the era of post-tenure burnout, but that's a result of the bullshit one has to endure in order to get tenure; after it, most are discouraged and spent.
I contend your wife likely will have to work, but she needs nothing like a high paying professional career. You just have to be able to eek out and survive on mostly her income for some periods of time, especially if you can live in a low cost area.