I'd say that a 20% ROI on the price of the development of the drug sounds reasonable. But the 11B was NOT the price of development; that would have been much lower. Assuming it was 1B (typical number thrown about), then a profit of 200M per year seems reasonable. Cost of manufacture of most drugs is negligible. Assuming they sell 100M pills/year, charging $10/pill (of $840/dose) seems quite fair.