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There's a lot of customer demand for VB.NET support:

There's one pretty cool feature that VB.Net has that C#/F# don't and that's an XML literal syntax... I wrote a service interface to a Flex client a few years ago (also having an XML literal syntax) and it was pretty nice going. Of course E4X didn't take hold and the syntax didn't make it into C#, but it was nice at the time.

These days I'd lean towards JSON.Net before anything XML based if I can avoid it. WCF could use a little love too.

Pretty much.

For example, we have a customer in health care area, where many of their researchers are using VB.NET for prototyping.

The type of stuff people on HN would use Python or R for, they use VB.NET.