Apple includes the ability to easily set up an IPv6 only hotspot. Using NAT64 and DNS64.
https://developer.apple.com/library/ios/documentation/Networ...
https://developer.apple.com/library/ios/documentation/Networ...
So, while the basic behaviour should be fine, it's best to set up a full-fledged IPv6-only access network, to ensure you can test the usage of the native IPv6 by the app as well, and verify there are no unexpected issues. (If the app talks to the resources that are IPv6-enabled, that is).