Downside is you see ads in your stream with mobile twitter which I don't see with desktop twitter.
Your stream doesn't feature ads? Mine is chock-full of them on desktop web.
None on desktop. Possibly due to uBlock?
Ah yes. What's curious is that uBlock doesn't block the mobile ones as well!
Then you close them. And they ask 'did you like this?'. And you say NO. Rinse and repeat.
They don't ask "do you like this?" anymore. They ask something like "show more like this?" and I'm afraid clicking No will remove tweets from people that happened to be in the "while you were away" section.