maybe the one place where you really shouldn't follow a strict grid is when you are using overlays. the darker box that contains the video is seen as being "on top" of the main title area. but the top of the video is aligned with the end of the title area. that makes the lower edge of the title area "carry across" into the overlay, which is confusing.

if you move the video down slightly then it will look more convincing / natural / real. you might also try moving the dark area right a little, so that the title area "sticks" out to the right. moving the entire dark area down slightly would also give the descenders in the title text a little more room (there's the same problem on the left below "better picks today" - are you trying to squeeze too much in "above the fold"?). you could gain some space by moving to a white background and losing the middle (white) layer / frame (yeah, like everyone else - but perhaps that's why...)

to me it looks very much like you / your designer has been following "grids" without thinking about when they make sense (although otherwise it does look pretty good / clean - just the small details that look odd).

also, why the huge footer (ff)?