Please keep in mind that my intent is not to mock you or your framework of choice. My goal with this post is to try to inspire you to try building something with the native DOM and Web API and see for yourself. Some may enjoy it, others may not. And if you feel comfortable with your current way of building your web applications with a framework, that's completely fine.
Also, please keep in mind that I cannot address every use-case in a single post. As much as I'd like to, that's going to take way too much time.