I have mostly gone back to plain ssh. mosh was fantastic for keeping a connection running across network changes and when accessing a plain command line it does feel a bit snappier on slow connections.

But screen or tmux give me persistence and re-establishing an ssh connection isn't very time consuming. A terminal multiplexer has a lot of advantages that mosh does not provide.

mosh adds another layer of terminal emulation and while the extra latency might not be a killer the terminal emulation can be as it is opaque to some features.