We've gotten used to huge commercial airliners flying on autopilot. Granted they have humans on board, but ask any pilot how much flying they do. Even helicopters can be put on autopilot after take-off. That's what the helicopters that run from Macau to Hong Kong many times a day are doing. I can see ironing out the kinks - pedestrians, roadblocks, car stops in front abruptly, etc... I would think you could have a truck lane only like the ones for buses entering the Lincoln Tunnel in NYC, and perhaps a guardrail that could have sections removed to open it up for traffic during less traffic times?