There is a long list of things about our technological civilization that would have benefited from applying the precautionary principle a little more. We're in damage control mode right now for a large number of environmental catastrophes, our agricultural techniques of the last half-century or so have depleted and desertified a large amount of prime arable land, we're rapidly shooting ourselves in the foot by abusing antibiotics, and we have some huge problems with war, poverty, and other kinds of social strife. In my opinion, we should be learning to think deeply through consequences instead of looking at our track record and saying "let's do more of that." We don't need to be absolutely sure, but given our history I think we could probably strive to be /more/ sure before we make irreversible changes.