Let's see how some examples go down:
"People say it's easy to make fun of retarded people, but it's not. You really have to explain it to them."
"My great grandmother threw herself in front of a bus. The police tried to say she had committed suicide but the family knew she was just trying to stop civil rights."
"I’ve spent the past two years looking for my ex-girlfriend’s killer... but no one will do it."
http://scomedy.com/quotes/Anthony-Jeselnik
The last special he made, he bombed so hard I just stopped following him. It's just hard to find things funny when absolutely no one else is smirking...