One group that self-medicates is people with psychosis.
People with psychosis smoke cigarettes; more of them smoke than the general population and they smoke more than the general population.
Hydrocarbons from cigarettes interact with, and reduce the efficacy of, antipsychotic medication.
That means people who have psychosis and smoke need more meds.
This - the side effects of strong medication, and the smoking - causes people with psychosis to die on average 20 years earlier than the general population.
It also causes a distressing number of house fires. (People smoking while sedated). People with psychosis are over represented in stats for death by home fire.
So smoking tobacco is probably a bad idea for that group of people.
When you add a psychoactive component that may[1] make psychosis worse it just seems like a terrible idea.
People with psychosis should probably have access to good quality early intervention teams rather than access to cannabis.
[1] one of the frustrating things of criminalisation is that it's really hard to do any research; and cannabis strains have moved onto strains that focus on THC rather than a more balanced mix of THC and CBD.