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Bostrom goes so far as to say that unless we rule out the possibility that a machine could create a simulation of a human existence, we should assume that it is overwhelmingly likely that we are living in such a simulation.
“I’m not sure that I’m not already in a machine,” he said calmly. http://www.washingtonpost.com/sf/national/2015/12/27/aianxie...
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Even if we rule that out, doesn't the possibility that we are in a simulation still exist? Maybe the creators of the simulation exist in an n-dimensional space, and the reality we experience is a gross simplification of that.
TBH, I find the idea comforting in a weird sort of way, as it gives a structure to everything (e.g. Of course quantum states only collapse when observed - why bother simulating something no one is looking at?).