Commercial with free versions: Game maker, Multimedia Fusion, Adventure Maker, Engine001.

Free: Tululoo Game maker (outputs to HTML5), Game Editor, Wintermute engine, Adventure Game Studio.

Programming languages: Browser Basic (Outputs to Html5), MonkeyX (desktop and HTML5, paid for other platform targets), BlitzBasic, BlitzMax, FreeBasic, QB64, Gideros mobile.

http://www.tululoo.com

http://pewtersoftware.com/browserbasic/

http://fbide.freebasic.net/download

http://www.qb64.net

http://www.blitzbasic.com

http://www.monkey-x.com

http://giderosmobile.com

Other game creation resources:

http://www.ambrosine.com/resource.html

http://freegameslist.weebly.com/game-creation-tools.html

A really good sprite editor:

https://sourceforge.net/projects/pixelaria/