We could drop hot reload but it is occasionally nice
The TypeScript tools for Visual Studio automatically regenerates the .js file every time you save its TypeScript file so it works statically without needing any background process to monitor for changes. So my JSPM doesn't know about TypeScript, it's just loading the pre-generated .js files every time I hit refresh.
If you've configured React Routing and are saving/reloading Redux state in localStorage on change it's a pretty good dev experience as most of the time a refresh brings you back to where you left off.