Well, problems with the default mode network seem to be linked to depression, Alzheimer's, attentional disorders, anxiety, and on and on. https://en.wikipedia.org/wiki/Default_mode_network#Pathophys...

My comment was meant about the positive effect that meditation has on DMN function through structural changes. My contention is that these changes are likely more permanent and longer lasting than the behavioral changes triggered by psychedelics. I am going to go out on a limb and say most people think it's better to experience lowered anxiety, depression and increased attentional capacity, which is what I meant.