For an OS, I run Whonix and have it configured so the system wipes the memory and shuts down immediately if anything foreign is attached or removed from USB.
Since I don't use any eSata or Firewire devices, if those ports exist I epoxy over them. There are too many ways to dump memory with direct DMA access.
If you were serious about a custom run of security-focused laptops, I think you would have a market for them. Dell and Lenovo just subcontract with manufacturers in China and it wouldn't be too difficult to contact one and give them the specs and do a custom run of laptops. Considering putting actual hardware switches for both the Wifi and Bluetooth.
I would certainly buy one!