There's a limit to what you can do without "simple" scaling, meaning, without making cheaper, faster, smaller individual gates. That is, an architecture optimized for a given problem domain will give you maybe 1000x efficiency improvement over a more general architecture, but that's it. (Typically it will be <1000x, but let's say you're lucky; the point is, that's your last 1000x, and then you'll see no improvements,
ever.)
So if Moore's law is indeed over, progress will be slow, domain-specific, and decelerating due to diminishing returns (specializing for a problem domain is worth it as long as that domain is not too narrow but at some point it's too narrow to justify the investment into building specialized hardware for it; you'll be better off using something less specialized. GPGPU, which does not provide amazing performance in an absolute sense, but does beat CPUs on a large range of problems, is an example to this - any accelerator more efficient than GPGPU needs to be justifiable in the sense that GPGPU is already there wherever there's a need for GPU doing graphics, which is where GPUs do provide amazing performance in an absolute sense [you can totally beat GPGPU with more specialized hardware on most benchmarks, while you can't beat GPUs in graphics.])
I'm a chip & accelerator architect, so it's not like I'm particularly happy about this, I think I'm realistic though. A higher-caliber architect saying the same pessimistic thing is Bob Colwell.
The one nice thing about really stopping at some manufacturing technology and not being able to improve any further is that the cost of using this technology will likely continue dropping for some years. Only when it reaches the bottom will progress have truly stopped.