We used it for a few years at Khan Academy before building KaTeX (https://khan.github.io/KaTeX/) which is around 50x faster to render in our experience, not even counting download size. We ran an A/B test for MathJax vs. KaTeX on the Khan Academy site and people completed measurably more exercises with the latter, even though they look identical. (KaTeX doesn't support everything MathJax does though – we still fall back to MathJax for a small fraction of our content.)
Please keep in mind I don't ask about open sourcing the mobile apps to help other developers, rather, it's to help KA. There are lots of contributions and improvements that would be made by the community if given a chance, which would benefit everyone. Contributions would have to be managed yes, but that's something that done all the time for other projects.
https://github.com/Khan/khan-exercises
https://github.com/Khan/perseus
https://github.com/Khan/live-editor
Contributions are few and far between; good contributions are even more so. It hasn't been worth the time investment, unfortunately.
With formula-heavy text, I'm forced to split documents artificially into multiple short pages to make rendering reasonably fast.
KaTeX looks quite promising, but it was missing support for quite a bit of basic markup the last time I checked. Perhaps it's better now.
I'd love to let people read my blog entirely in their RSS reader. But unfortunately most of my posts won't render there.