Wut?
Here's the results of me changing an "add to cart" button from a branded looking maroon button to a simple yellow (Amazon style) button: http://cl.ly/0d440I3T333m
That's 26% sales increase from changing a button's color.
If you've got a good eye for usability, your intuition is going to lead to a lot of fun and great results with A/B testing. If not, you'll futz with things that make no difference most of the time and eventually give up. Experimentation is not about testing random permutations (unless you've got an infinite amount of time). It's about coming up with a reasonable hypothesis and then testing it. I study a web page until I come to a conclusion in my mind that something could really use some improvement. Then, even though I'm sure of it in my mind, I test it, because "sure of it in my mind" is wrong about half the time.
One note to those who use Optimizely: you do need to wait at least twice as long as Optimizely thinks, because statistical significance can bounce around with too little traffic. Optimizely thought the above test was done at about 2000 views, which was far too little results to be conclusive, with only ~20 sales.