A Virus That Could Cure Alzheimer’s, Parkinson’s, and More | Hacker News Reader

A Virus That Could Cure Alzheimer’s, Parkinson’s, and More

pbs.org

123 pointssharp1110 comments

Warning, another early stage trail drug!

Phase I <-- They are here

Phase II 18% proceed to phase III [1]

Phase III 50% succeed. 25% for first-in-class agents, which it sounds like this one is. [2]

So if this phage passes its current phase I trials, it would then have a 5% chance of eventually getting to market. The current probability of success would be even lower because it hasn't yet completed phase I.

[1] https://en.wikipedia.org/wiki/Phases_of_clinical_research

[2] http://www.forbes.com/sites/davidgrainger/2015/01/29/why-too...

Also the mechanism by which it works (eliminating certain protein aggregates in the brain) might not actually be related to the cause of Alzheimer's. Many other drugs targeting these aggregates have failed.

It could be that it's like trying to cure the flu by taking tylenol - sure you get a fever when you get the flu, but it's not the root cause.

But I hope it works!

But would it ultimately not matter if you aren't cured? To use your analogy, tylenol takes away some of the symptoms, if this takes away the symptoms of Alzheimer/Parkinson's from an outside observer's perspective you're "cured." Even if in reality you aren't and have to take this for the rest of your life.

Yes, except other drugs designed to clear the plaques have been tested and they've all shown no reduction in symptoms. So my flu analogy was not great :)

But it's absolutely possible that the prior drugs were all tested wrong or didn't quite do what we thought they did. That is not sarcasm, sadly.

The analogy is flawed. These proteins might be a cause of the symptoms, or an effect of the disease, but we don't know that they're related. A better analogy might be, that this could be as effective as trying to eliminate a pigeon infestation by sweeping up their feathers and scrubbing out the crap.

The drug companies would love that outcome wouldn't they:

Sick for the rest of your life === $$$

instead of dead or mentally disabled?

People with Alzheimer's would love it too, because the status quo is that your memory deteriorates and then you die, and there's basically nothing you can do about it.

As the saying goes: "Despite the increasing cost of living, do you notice how popular the option remains?"

It's interesting that just putting M13 in the nasal passages of the control group of mice "showed very nice recovery of their cognitive function" - if I read the article correctly.

I wonder if someone could try that in humans in some less FDA obsessed country given that "M13, the phage was originally isolated from sewage in Germany 50 years ago" and so is presumably not that hard to come by.

My dad has Parkinsons like deterioration at the moment and it would be nice to have some recovery of cognitive function now rather than waiting for the treatment to be officially approved after he's been dead for a decade or two.

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