For that, broadly, supply new, valuable information. For that, take in available data, manipulate it, and report the new information as the results.
So, with all this data, find where some new, valuable information will make a good, new product/service. Then to have the first good or a much better offering, do use much more powerful data manipulations. For that, the secret is, and the candidates are, object oriented programming, processors with 1000+ cores, processors with clocks at 50 GHz+, new programming languages, new computer architectures exploiting, say, solid state disks addresses as a slower version of main memory, processors communicating with optical instead of electrical signals, quantum processors, massive parallelism of the cloud, original derivations with theorems and proofs in applied math exploiting appropriate advanced prerequisites, and may I have the envelope please [drum roll], and the winner is -- applied math!
Sorry 'bout that. Here the applied math is replacing the current ubiquitous elementary techniques, intuitive heuristics, fitting to large data sets, and copying what was long done manually.
This answer will not serve everyone or please everyone, but IMHO it is the most promising, single path forward.