Sex Is a Coping Mechanism
nautil.us
nautil.us
I would recommend you to read https://en.wikipedia.org/wiki/Punctuated_equilibrium for a start.
What does punctuated equilibrum have to do with it?
tend to be subtle and become evident only over many
generations, [while] its costs are heavy and immediate
and so sex *seems* like a waste
emphasis mine. Your reading of the article is extremely uncharitable.This is entirely impossible with asexual species - the strains would merely compete with each other and nothing interesting would happen.
Off the top of my head, I can imagine possible adaptations which humans would find strictly beneficial, but we won't likely evolve (without genetic engineering). E.g. there's no good reason why humans have a blind spot. We wouldn't have it if our optic nerves were attached behind our retina instead of in front. But we're stuck with it because evolution can't conjure a discontinuous jump in our anatomy.
2 parents can have more children than 1 parent. Hermaphroditism means twice as many offspring with 1/2 as many copy's of your DNA.
Even single celled organisms will exchange DNA.
This arithmetic becomes ugly fast for asexual reproduction.
On the other hand, in a sexually reproducing organism, a disadvantageous mutation can be masked if recessive, and selective pressure will only remove homozygotes from the population. The end result is that harmful mutations can stick around for a long time, and even accumulate in individuals.
In asexual case, an individual with one advantageous mutation and ten slightly disadvantageous will be flushed out.
In sexual case, such individual will produce some survivable offspring and the advantageous gene has good chance of flourishing in the population.
A lot of insects can reproduce asexually but they are also capable of sexual reproduction. Ones who are not eventually die off.
And yes, optional sex is almost certainly how sexual reproduction arose. Even today I'd wager there are more facultatively sexual organisms than obligate sexual. That's a non-sequiter, though, as even optional sex would be bred out of a population if it could not show a benefit in a small number of generations.
It could have involved very unlikely events.
It's obvious how a sexual plant that is able to obtain the beneficial mutations from the other two populations would gain a major and immediate advanage.
This paper presents a hypothesis that explains how sexual reproduction could be more advantageous than asexual reproduction after one generation. This is what makes it novel and new.
It's two generation with or without selective breeding. The first generation will have individuals with three or four beneficial mutations, the second will have some with five. (assuming the traits are dominant)
But this is with only one gene. Imagine there are five a, b, c, d and e. An individual with all five will arise much sooner in a sexual species.
The evolution of sex isn't a mystery any more than an eye is a mystery. It's not all or nothing. Life didn't go from bacteria to peacocks in one step. You can have something like optional hermaphrodite sex (in mollusks, I think) where you can exchange genes when the conditions arise, but it's not mandatory. The costs are virtually zero, but the benefits are still there. But then it becomes advantageous for idividuals to cheat and impregnate others, without producing eggs themselves and you get separate sexes.
And yes, once you get to more mutations then sex is more advantageous for a number of reasons. No one is claiming that sex is not better over long enough time scales. The question is how can it be advantageous enough to become fixed in a population over the span of a couple generations.
And yes, sex did evolve gradually. Slime molds have optional sex (and more than 2 sexes!). But still keeping the machinery around is expensive. One would expect that individuals that ditched it would outcompete those that kept lugging it around unless there was a relatively short-term benefit to sex.
It doesn't need a long timescale, asexual species get out-evolved by sexual species and go extinct eventually. Sexual species have a much higher probability of entering new niches or surviving when the conditions change. This can be seen in many species that reproduce asexually when the conditions are good, but reproduce sexually when stressed.
A species that loses the ability to reproduce sexually is doomed to extinction. Asexual reproduction is essentially putting all your eggs into one basket. When you die of a disease for example, chances are that most of your offspring dies as well AND there is a much higher chance that the disease adapts to your genome in the first place. This can be seen in agriculture, where plants are reproduced asexually to a much bigger extent than what would happen naturally. Many are impossible to grow without heavy doses of pesticides, as the diseases quickly adapted to the commonly planted strains. The strains need to be replaced every few decades, before growing them becomes essentially impossible, even with pesticides. Evolution is much faster than you assume.
Scale this up to 1000 individuals, each with mutations that are advantageous or disadvantageous, which impacts their chance to have children, and run it across a few generations (with a small chance of children getting new mutations not in their parents), and the chance of a subset of the population getting many of the positive mutations is much much higher than if they were an asexual species.
The asexual species will end up with more member of the final population having the single most advantageous mutation, but with none having more than that.
In other fields, it can be simply because it is prohibitively difficult or expensive to instrument the quantity of interest. This is extremely common, even in the 'hard' scientific fields and engineering. You very, very seldom have all the data you want.
This is all a long winded way of saying that confirmation of a hypothesis by mathematical models certainly is a mechanism by which science creates a stronger degree of belief in said hypothesis. Would it be a full fledged validation of the model? Probably not. But it is absolutely useful evidence.
Full disclosure, I am a computation scientist.
I believe that models are certainly wrong. I personally doubt we have any models that actually reproduce the underlying mathematical structure of the universe (if it even exists, as you noted).
...But some models are useful. And when viewed from that perspective, a mathematical model can provide evidence that a hypothesis accurately explains an observed phenomenon, given a certain set of assumptions.
I view validation of a model hierarchically, where a untested hypothesis gains credibility by increasing tests of the validity of its predictions. Direct experimental confirmation is the strongest, but this is almost always impossible, and so weaker forms of testing are necessary. Computational modeling certainly provides a weaker form of confirmation, from this perspective.
[0] http://chem.tufts.edu/AnswersInScience/RelativityofWrong.htm
Mueller's model assumes that fitness decreases as a linear function of deleterious mutations. In simplified terms: Got n bad mutations? You're more likely to reproduce than someone with (n+1) bad mutations.
In an asexual population, individuals will have the set of mutations plus those acquired by mutation from their time of divergence. When you add sex to the mix (ha!), your population stops looking so flat. It introduces variance and selection culls the maladapted individuals. What's really cool about this, is you can model the deleterious mutations being driven out of the population.
Kondrashov's model is even more powerful. Basically, it says that there's some capacity for deleterious mutations. A couple of things wrong? Yeah, you'll reproduce. Too many? Well, you stepped off an mutational cliff and you aren't long for the world. This step function actually removes deleterious mutations from the population faster than Mueller.
The advantage of sex is obvious even on an individual basis. We all should have a chromosome that's "worse than average". When you mix and match them among your gametes, you'll end up with some non-viable gametes and some superstars. By failing fast, any parental investment can go toward offspring who are more likely themselves to be viable.
[For more information, check out Gillespie's Population Genetics]
2. Even accepting the premise, it doesn't explain why sexual reproduction should be favored over asexual reproduction with occasional conjugation.
3. Even assuming that this mechanism is sufficient to explain the advantages of sexual reproduction, it still operates over a long time scale (i.e. long enough for enough deleterious mutations to accumulate in the asexual reproducing population).
What this comment and the parent (and many of the others in this thread) fail to understand is that no one is debating that sexual reproduction is advantageous over long enough time scales. The question that the authors of the original paper are addressing is how sexual reproduction could be advantageous enough on a short enough time scale sufficient for those organisms to avoid being outcompeted by asexual organisms.
Finally, this house would like to remind the honorable gentleman that he is invited to comport himself in a civil manner.
Claiming that the entire premise of a course of research, on which numerous scientists with extensive training have worked, is "false" is just filled with the worst sort of hubris.
Leaving claims of hubris aside, I think some of the sibling threads are a tad mistaken. For example, population size is a determiner of the rate of neutral drift. I'm trying to work through what are the implications to having more genealogical ancestors than genetic ancestors, but it isn't immediately clear.
If you really want your mind blown, check out Art Poon's paper "The Rate of Compensatory Mutation in the DNA Bacteriophage φX174" and Daniel Weinreich's "Darwinian evolution can follow only very few mutational paths to fitter proteins". Both have some amazing evolutionary implications.
One way to understand is to look backwards at a single individual's ancestors. In an asexually reproducing species, the number of ancestors is O(n) in the number of generations you look back – and in any prior generation the individual has exactly one ancestor. In a sexually reproducing species, the number of ancestors is O(2^n) until you reach the point (surprisingly rapidly) where the whole species either is an ancestor or doesn't have any surviving descendants.
Why does this matter? Because multiple beneficial mutations are far more likely to have arisen in the O(2^n) ancestors in the sexual scenario than in the O(n) ancestors in the asexual scenario. In other words, sexual reproduction allows beneficial mutations to occur independently in any pair of unrelated individuals in a population and eventually both mutations will spread to the whole population – the whole species ends up with all the "winning" mutations. With asexual reproduction, unless two mutations just happen to fall on the same lineage – which is very unlikely – they will compete instead of merging, because there is no mechanism for merging lineages.
Bottom line: in asexual reproduction, independent mutations compete; in sexual reproduction, they can cooperate. Sexual species literally evolve exponentially faster than asexual ones.
Below I've linked a nice blog post on the question, as well as a Nature review from 2002 and even a Nature article from two weeks ago (Mar 2016).
http://sandwalk.blogspot.com/2014/03/everything-you-thought-...
http://www.nature.com/nrg/journal/v3/n4/abs/nrg761.html
http://www.nature.com/nature/journal/v531/n7593/abs/nature17...
Let me quote from one of them:
"The vast majority of species engage in some form of sex or genetic exchange. Yet the evolutionary forces that make sex widespread in nature remain incompletely understood. In principle, asexual reproduction should be more efficient: it avoids the costs of mating and allows individuals to pass all (rather than half) of their genetic material to their offspring. Extensive theoretical work has sought to understand why sex is pervasive despite these substantial costs."
This is not, however, what TFA is about. It is covering a course of research that is investigating whether or not sexual reproduction compensates for the difference in mutation rates between mitochondrial and nuclear DNA. You've managed to fill an entire thread with attacks on the introductory paragraph from a science journalist without once addressing the research being reported upon.
There is no such a cost of sexual reproduction. We need to separate sexual reproduction from having separate sexes. Hermaphrodite reproduction isn't very costly, the only cost is the cost of the sexual act itself.
Then, however, hermaphrodite reproduction is unstable, since it's obviously beneficial for the individual to only impregnate others, without prodicing eggs itself, and so passing the most expensive part of reproduction to others.
Then, the next question is why the females don't revert back to asexual reprodction, but 1. that has been observed in many species. 2. Purely asexual lineages tend to die out soon and 3. it's partially counterbalanced in many animals by the male providing some other benefit, like giving food to the female or taking care for the offspring.
While this is indeed somewhat paradoxical, it's in no way a mystery.
Another problem with this theory is that symbiosis and mutualism are not uncommon in nature. The way this problem is typically prevented (and it seems to be even a necessary condition for mutualism to remain stable, or even arise in the first place) is that there is some mechanism for culling or cutting off the symbionts that fail to provide the expected benefits. There is no reason to believe that the same isn't the case with mitochondria. Sex seems to be a very heavy handed way of doing so, and if it was so, you would expect people to die randomly without a clear reason when their mitochondria happen to mutate the wrong way.
And that recombiantion thing, that actually does happen, it's known as "outbreeding depression" and probably one of the reasons why species arise.
Definitely trying this one.
Really? I was taught about mitochondria in considerable detail as part of the biology part of my undergrad science degree & mitochondria have clearly been studied pretty intensively. That’s not to say that there aren’t gaps in our knowledge or new things to learn, but the idea that the mitochondria have just been ignored is clearly untrue.
I guess some researchers feel it necessary to talk up their own research though - it’s a labrat eat labrat world out there.
Shortly after Dolly the Sheep became famous, Ian Wilmut (one of the main people of that project) visited my university for a talk, and I asked him if he was concerned about the impact of mitochondrial differences between the genetic donor and the host egg. He was quite dismissive, saying (IIRC) "mitochondria are responsible for at most 5% phenotypical expression".
To me that sounded like a lot (and I had asked the question because I expected mitochondrial differences to really matter) but he did not share my view.
So, yes, if Dr. Wilmut's reaction was typical, I think it's fair to call that "ignored". Not "unknown", but ignored.
I mean, click-bait or not, the idea of referring to an innate part of the biology of animal life as a "coping mechanism" automatically leads to a form of nihilism.
I'm not religious and I'm certainly not a proponent of orthodoxy in nearly any aspect of life, but I always feel that trying to transcend naturally existing things is a fool's errand. One example is illustrated by our recent understanding of antibiotics and how they destroy our gut biome, and how that might be a really big problem.
You say that like it's novel...
It's been the almost universally accepted opinion in philosophy for the last 100 years or more that post-Enlightenment man is Nihilist because he denies his traditional narratives. It's the big story of the 20th century. Everything from Nazism and WW2, to the divorce rate has been blamed on it... Where have you been?
I'm not worried about "every little detail". I'm concerned with basic areas of human knowledge, foundational elements of a classical education.
I'm concerned that we're creating engineering-educated drones capable of industriously automating away our traditional roles, yet who haven't even had the proper post-Enlightenment education to understand the civilization in front of their eyes.
I think it has a lot to do with the instrumentality capitalism wants from its participants -- and we seem to want to use science to make us better cogs rather than better humans. Its a pretty old idea stemming from the industrial revolution -- it just seems that today we're more 'loosely coupled' into the system which gives us just enough of an illusion of freedom. e.g. you can choose a job, but you can't choose not to have a job, you can speak freely, but you'll be monitored etc.
Because of this I have recently had a resurgence of volunteerism and religious soul seeking. I've found it refreshing that these two arenas seek earnestly to humanize through giving.
also, if giving is your metric you'll be better off looking to capitalism and secularists
As an aside, OPs conspiracy theory about the article titles sounds really silly.
You're operating under a false dichotomy, and frankly, it's the type of misguided reasoning in the face of new evidence that leads to farces like the Scopes trial and decades of perceived conflict between science and humanity.
The article is on the biological origin of sex, not the multiple facets of sex in human culture today. That's not evidence of a conspiracy.
did you read the article? using 'coping mechanism' in the headline reads like an intentional joke, subverting its audience's expectations
replace coping with regenerative or restructural or restorative and you have a clearer take on the article
the authors argument is a biological one
about the benefits of sex, versus asexual reproduction, encouraging and repairing mutations on a cellular level
the idea of it applying to the entire organism is only slightly touched on in the last few sentences, again, as a seemingly mocking jab at the notion of sex being a psychological 'coping mechanism'
to the effect, 'you're right it is a coping mechanism, sex copes well with evolution's affinity for variety quite well'
that said, to directly address your dehumanisation:
sex is a coping mechanism
and it is expression of self, and it is physical form of progeny creation, and it is a social construct, and a whole lot more to a whole lot of different people for different reasons
denying that sex helps some humans cope with other issues seems rather dehumanising to those people
but again, this is just addressing your comment, the article is about something completely different
If by that you mean centuries, I'd agree. Dehumanization of classes of people is a feature of human civilization going back to the beginning of human civilizations. Look at the link you posted. Right at the top is a picture that proves the point.
There's no conspiracy. It's what we do, it seems, for better or worse.
This article in particular though, I don't really see it? It's biologists suggesting a model for understanding features of human evolution. It doesn't at all suggest we treat people with disrespect en masse. It doesn't at all suggest we censor a class of humans for political/economic gains.
You want to shine light on a conspiracy to dehumanize? Try going after something that matters. Like wage labor, student debt, consolidation of wealth... All which are truly dehumanizing facets of our society that impact people on a wide scale. This article is biologists comparing notes in a very limited context, with very limited power/authority to subjugate people.
This post reads like paranoid ramblings of someone unable to compartmentalize things into appropriate context.
All this group is saying, in essence, is that instead of that pressure coming in the form of infrequent external events (plagues, floods, asteroids, etc.), it is present for every generation in the form of dealing with mitochondria that don't quite fit any longer. An interesting idea, to be sure.
Some species' sperm do pass mitochondria successfully. Human sperm passes mitochondrial dna, but the egg kills it off.
I'm interested in this though: do you know any examples off the top of your head where the male passes on mitochondria? I thought the primary reasoning is that sperm is little more than DNA with a tail and engine attached. (poetically speaking)
No, I don't know.
I had thought you were saying the sperm had mitochondria and the egg killed THE EGGs mitochondria off.
My mistake.
A mother needs to provide a complete eco-system (uterus) for the baby to live and grow which affects even the hormonal system.
A man doesn't need this, so he can use this energy or "program space" in his genome for other things.
It's one of Dawkins theses in his superb book "The selfish gene" [1] where he basically reduces evolution to game theory (without explicity saying so).
On the other hand though, in e.g. lions, it's the females that go out hunting the most. I'm not sure what the logic is there. Maybe the males die a lot in fights for dominance and territory so they get to be lazy?
I suppose the lone lions hunt for themselves (and you probably didn't count those) while the leader of a pack doesn't need to because he is the respected, well, leader.
But isn't the "flaw" already taken care of: the heavy and immediate costs are very much compensated by the pleasure and high stimulus which are as immediate as anyone who has gone through puberty knows. (And which are not unknown in the non-human part of the animal world either.)
Stopped reading after this. If it's straw man, it's an especially stupid one. If she is serious, that's not even funny.
I really don't like the title, it looks like a confusing linkbait. Following the unofficial extended guidelines, I suggest the subtitle that is much better: "Did sexual reproduction evolve to keep up with mitochondrial mutation? "
That link lies in the fact that mitochondria are not just cellular batteries. Billions of years ago they were actually independent organisms. They are an example of how the human body is not entirely “human.”
and (quoting someone else):
“Until recently, science has basically ignored the fact that we are all walking around with two genomes in every cell,” Dowling says, “that of our own nuclear genome, and that of the mitochondria.”