As someone who used to work at a startup that used Postmark to send alerts, I think its just easier for our small company of less than 12 people.
They provide a fairly easy to use api, and a graphical user interface to monitor sends, they automatically stop sending if a user requests so you don't get marked as span. Of course that happened to us twice, one time the user then inquired why they weren't getting the email alerts....
For us our public facing information website, was controlled by the business dept, not the same as our functional site, done by the engineering side on AWS (before AWS had mail...). So it allowed us to send from the main domain without being put right in the spam folder.
I used Mandrill for a small non-profit site, very low volume, so I'll be moving to probably one of these providers.