I find in my line of work, which I think the average person would rate as very intellectually demanding, I find my lack of social connections to be my greatest weakness!
Hard problems might need solitude, but really hard problems seem to need multiple minds and perpectives to solve.
I of course need alone time, but only on focused portions of what adds up to a far broader and more cooperative strategy.
I've also found the smarter you are, the more likely you are to look down on larger portions of humanity, and it multiplies in higher density regions. This is a pathway to unhappiness that seems to be rooted in my own ego though more than an objective reality.