In theory, couldn't a lot of heart disease (if not more general cardiovascular diseases) be addressed by figuring out how to affordably grow new hearts from tissue? I understand that's not something we're capable of doing right now but from my (largely ignorant) perspective, it seems like the issue is "hearts break down over time". The heart is essentially a mechanical part, and unlike neurological systems, there's no qualitative difference between one heart and another aside from how well it pumps blood. When you have a mechanical part that wears out, you replace it. Artificial hearts have issues stemming from the fact that they aren't 1:1 replacements for human hearts but if you could grow a new heart from a person's cells and get to a point where doing so is relatively affordable, could you not swap out an old heart the way you'd swap out a fuel pump that's wearing out?
Compared to stuff like cancer, I feel like replacing hearts is more an issue of cost and engineering rather than developing entire new forms of treatment.