The person plotting to commandeer the cockpit always has the upper hand, because they'll be the first to act. It's hard to defend against a sucker punch or a knife from first-class.
You could even argue that the two-in-the-cockpit rule is less secure, because it introduces one additional person who could pull off a germanwings scenario into the impenetrable control room. This is the same concern raised by the pilot quoted in this article (http://www.smh.com.au/business/aviation/germanwings-australi...):
"It exposes the cockpit to more security risks than the isolated case of a homicidal pilot," he said. "I think flight crew are a better judge of fellow pilots' mental state. Now I have to judge the cabin crew member's mental state too before leaving them in the cockpit with access to things like the crash axe."
Originally I had a long aside in the article to deal with this point, but I axed it because I don't think it changes the core argument. Unfortunately Medium seems to have removed footnoting capabilities. But it's still a valid note. Thanks.