IMO the better combustion engines become, the more options for fuel we have. For example, ethanol compares poorly to gasoline in power & consumption, but with continued engine development, ethanol will be able to develop as much power & economy as gasoline does today.
It would be better for smaller applications to move to electric and produce energy by other means. This requires investment into better batteries/storage applications. I'd rather all the money go to that instead of combustion research.
There are still a lot of places where very high power to weight ratio of combustion engines is extremely important.
I'm talking cars, bikes and the like...
EDIT: Also, a 737 does not use the type of engine described here, unless you want them to move back to prop design.
But my apologies, I did miss the "small application" part.
It's definitely useful to burn less fuel, but still.